Protein in vaccine8/10/2023 ![]() Another widely used and successful VL drug Miltefosine tends to have teratogenic effects in animals. Application of Amphotericin B provides a cure rate of more than 98 percent but causes fever, chills, thrombophlebitis, and in serious cases nephrotoxicity. Pentavalent Antimonials which are widely used drugs for VL is being proven less effective due to drug resistance mainly in India. Currently, anti-leishmanial therapies, based on chemotherapeutics are available but drug toxicity and numerous side effects set a huge drawback. More than 50,000 annual deaths due to leishmaniasis have been reported by The Global Burden of Disease Study (GBD) in 2010. In these countries, leishmaniasis is a significant health issue and sets a huge impact on socio-economic conditions. 90% of worldwide visceral leishmaniasis cases have been reported in Ethiopia, India, Bangladesh, South Sudan, and Sudan, Brazil, Kenya. The disease is endemic in more than 60 countries, with an estimated 50,000–90,000 new cases of visceral leishmaniasis occurring each year worldwide. Visceral Leishmaniasis (VL) is the deadliest form of leishmaniasis which is caused by Leishmania donovani in South Asia (India, Bangladesh, Nepal) and East Africa (Sudan, Ethiopia, Somalia, and Kenya) and by Leishmania infantum in the Middle East, Mediterranean, Brazil, Pakistan and Iran. Sandflies mainly of the genus, Phlebotomus and Lutzomyia are known to spread this disease. The genus Leishmania belongs to a family of Trypanosomatidae of the order kinetoplastida. Leishmaniasis is a vector-borne chronic inflammatory disease, caused by the protozoan parasite of the Leishmania genus, transmitted to humans by sandflies. Further wet lab synthesis of the vaccine and in vivo works has to be undertaken in animal model to confirm vaccine potency. The above bioinformatics data support that the construct may act as a potential vaccine. In-silico codon optimization and cloning of the vaccine nucleic acid sequence have also been achieved in the pET28a vector. ![]() In-silico immune simulation studies confirms the vaccine to raise a pro-inflammatory response with the proliferation of activated T and B cells. ![]() Population coverage analysis shows the vaccine can be effective on the majority of the world population. The predicted tertiary structure of the vaccine has been found to be valid and docking studies reveal the construct shows a high affinity towards the TLR-4 receptor. The vaccine construct is generated by joining the epitopes with specific linkers. ![]() The various physicochemical characteristics of the vaccine have been explored and the tertiary structure of the chimeric construct is predicted to perform docking studies and molecular dynamics simulations. We have chosen four antigenic proteins of Leishmania donovani and identified their T-cell and B-cell epitopes, utilizing those for in-silico chimeric vaccine designing. With the advancement of bioinformatics and its application in immunology, it is now more convenient to design multi-epitope vaccines comprising predicted immuno-dominant epitopes of multiple antigenic proteins. Conventional vaccine synthesis techniques are often very laborious and challenging. VL falls under the category of neglected tropical diseases with growing drug resistance and lacking a licensed vaccine. Visceral Leishmaniasis (VL) is a fatal vector-borne parasitic disorder occurring mainly in tropical and subtropical regions.
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Keith Savasten, Knowledge Manager - Overland Park, KS ![]() Jim Zehren, Retail Sales Manager - Overland Park,KS Susan Hall, General Manager - Overland Park, KS ![]() David Bruno, Knowledge Manager - Chicago, IL ![]() Roger Lewis, Operations Manager - Chicago, IL Edcular Crenshaw, Retail Sales Manager - Chicago, IL Glen Rorison, General Manager - Chicago, IL Matt Webb, Retail Sales Manager - Columbus, OH Jessica Nelson, Knowledge Manager - Tustin, CA Chris Olexa, Retail Sales Manager - Tustin, CA Jim Rhodes, Knowledge Manager - Brentwood, MO Scott Youngblood, Operations Manager - Brentwood, MO Aaron Nolte, General Manager - Brentwood, MO.Matt Lyons, Knowledge Manager - Sharonville, OH Tonya Johnson, Operations Manager - Sharonville, OH Jeff White, General Manager - Sharonville, OH Nicolas Carranza, Knowledge Manager - Westmont, IL Leo Chavez, Operations Manager - Westmont, IL Miss Katie Ryza, Retail Sales Manager - Westmont, IL.Layda Cardoso, General Manager, Westmont, IL Patrick Raeihle, Knowledge Manager - 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Duluth, GA Belynda Green, Retail Sales Manager - Duluth, GA Dedrick Swain, General Manager - Duluth, GA Demara Leos, Knowledge Manager - Marietta GA Mike Grant, Operations Manager - Marietta GA Dan Ivy, Retail Sales Manager - Marietta GA James Brady, Operations Manager - Mayfield Heights, OH Coy Stephens, Operations Manager - Columbus, OH Andrew Burris, General Manager - Marietta GA Tom Welsh, General Manager - Columbus, OH Chris Tripodo, General Manager - Mayfield Heights, OH Albert Rogers, Customer Relations Manager Spy network mtg standard8/10/2023 ![]() A full refund of the purchase price for the affected product (including postage, where applicable).ĭragon's Lair Salisbury will always work with you to fully understand the extent of your inquiry and to deliver an appropriate and satisfactory resolution for you. ![]() A replacement of the entire faulty product (including postage paid by us, where applicable).A replacement of the faulty part (including postage paid by us, where applicable).If we determine the product you have received is indeed faulty, you will be entitled to one of the following remedies: We asses all claims on a case-by-case basis and will respond to you within 48hours. ![]() Photographic evidence of the defect or damage, including the state of packaging, where applicable.If you have received an item you believe to be damaged or defective, please contact Customer Care (through our Help widget below, right) providing: Products which include cards subject to a random draw, including TCG products.Products specified as a random assortment of potential items where a specific item was not received.Unfortunately there are some cases where an item may be received damaged or defective due to errors encountered in manufacturing by the product’s publishers, or by our courier partners.ĭefective items include (but are not limited to): ![]() We endeavour at Dragons Lair Salisbury to provide the best gaming experience for all our valued customers and we work hard to ensure our stock is free from damage or defect prior to leaving our warehouse. Please note: we are currently unable to process any exchanges via post. Note that online refunds are provided for the product only and do not include reimbursement for any shipping already paid. If return postage is not paid by the customer within 14 days of the customer being notified of their return inspection outcome, the product will be considered abandoned and we will dispose of it. It is an expectation that our customers advise us of any issues relating to their order prior to returning the product to us for consideration.Īny returns deemed non-complaint with the above conditions will consequently not be eligible for a refund or exchange and will be held at our warehouse until such time as the customer returns to collect their product or pays to have the product re-shipped.
Best chess opening moves8/10/2023 Preferred by World Champions – 1.d4 moveįor many World Chess Champions, including Anatoly Karpov, their most preferred opening move is 1.d4. Take a look at this article that talks about Sicilian defense variations. Also, players who prefer open positions can choose to play the Alapin (2.c3). However, the theory can be minimized by playing one of the Anti-Sicilians. Many beginners get confused and disheartened by the amount of theory involved in the Open Sicilian. Often, when a White plays 3.d4 and 2.Nf3, that will acquire them central space, but it will ultimately benefit the Black if they interchange a central pawn for a bishop’s pawn. ![]() It is regarded as an aggressive chess opening for the Black pieces and is also very popular. Sicilian Defense (1…c5) is one of the best chess openings for Black against 1.e4. The 1.e4 chess openings are also declared as ‘best by test’ by Bobby Fischer. This strategy is known as ‘developing with tempo’. And, when the Black pieces recapture the queen, then by playing 3.Nc3, we can attack the queen and develop our knight simultaneously without any extra moves. If the Black does so, then we can capture the pawn. The 1.e4 move also makes it more challenging for the Black to play 1…d5. These pieces are the Queen and the Bishop at f1. Choose 1.e4 as your chess openingġ.e4 is considered as one of the best chess opening moves for White, even at grandmaster tournaments, since it immediately sets up a possibility to develop two pieces. The following chess opening moves should be kept in mind to start well in the initial phase. Play online games like Ludo, Snakes and Ladders, and Trump cards on Zupee! Download the app and stand a chance to win 10 Lakhs! 16 Best Chess Openings Now play skill-based strategy games with quick gameplay and easy rules. Moreover, they either develop a piece or make it possible to do it on the next move.īefore we move forward, you should have an understanding of how to play chess, chess rules, and fundamental strategies that you can apply. These moves attack at least one central square. Therefore, it is crucial to understand the three phases of the game of chess:įor a beginner, the best chess opening moves are 1. ![]() But, without any game plan, we would get frustrated and end up staring blankly on the board. The game plan may sometimes work or may not in some positions, even for the masters of the game.
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